Boris Johnson’s right-hand man Dominic Cummings left Downing Street after a power struggle that rocked the Prime Minister’s administration.
Dramatic events set a deadline of December 31 for change, ahead of key Brexit talks with Brussels.
Sky presenter Sophie Ridge said: “It is unbelievable to think that the Prime Minister has lost two of his most important things in a week – at such an important moment – one step back and could have profound consequences for the future of the UK and Europe. .
“What is clear is that this marks an important moment for Boris Johnson.
“Last week’s battle saw an old guard burn to the ground – we don’t know what will emerge from the ashes.”
Meanwhile, he said there was a “screaming” confrontation between Mr Johnson and Mr Cummings over the ousting of Mr Cain, and that a “brighter” prime minister would prefer both “sooner”.
Some reports suggest Mr Cummings resigned immediately, while others suggest he and Mr Cain will be hired until mid-December.
Many Conservative backbones have urged No. 10 to use this as an opportunity to reclaim many important values within the party.
Senior Tory MP Sir Bernard Jenkin said it was time to restore “respect, integrity and trust” to the relationship, elements that were “absent in recent months.”
The Daily Telegraph reported that tensions were high within No. 10, with Mr Cummings accused the prime minister of making “explanations”.
The newspaper told Mr Cummings colleagues that Mr Johnson was “beyond doubt” and that he and Mr Cain had relied on Cabinet Office Minister Michael Cowie for clarity.
It was also suggested that a faction led by Mr Cummings and Mr Cain “outspoken against him” and his fianc மனைவிe Gary Symonds had angered the Prime Minister.
Meanwhile, Shadow Health Secretary Jonathan Ashworth noted the mobilization by the Covit-19 on the NHS and the general public, while “Downing Street is paralyzed by this self-agitating spin doctors’ soap opera”.
James Slack, the prime minister’s official spokesman to replace Mr Cain in the new year, insisted Mr Johnson had not been continuously distracted from the national crisis.
“The focus of the Prime Minister and the government is to take all possible steps to get this country through the corona virus epidemic,” he said.