Broncos open touchdown favorites in Week 1 vs. Titans

The schedule is out and the Denver Broncos will host the Tennessee Titans in Week 1. Here are the odds!

Week 1 opening odds are out now that the 2025 schedule has been released. The Denver Broncos will be playing at home against the Tennessee Titans and their rookie number one overall quarterback pick, Cam Ward.

According to FanDuel, the Broncos open 7-point home favorites to the Titans in Week 1. The over/under stands at 40.5 for this matchup.

Broncos vs. Titans betting odds

Tennessee Titans at Denver Broncos
Sunday, September 7, 2025 at 2:05 P.M. Mile High time
Empower Field at Mile High in Denver, Colorado
ATS Betting Lines: Denver -7
Moneyline Odds: Denver -360 / Tennessee +290
Over/Under: 40.5

With the Broncos defense looking like it does on paper, this figures to be a real test for Ward in his NFL debut. I would have to give the edge to Denver even if I weren’t already a Broncomaniac who bo-lieves in this team completely. I somewhat expect the Broncos offense to start the season a bit slow, but I do not expect the same from the defense.

A full touchdown spread seems way to high to me for a Week 1 game, but I could have my judgement clouded by the fact that the Broncos offense just hasn’t been that good for so long that I just expect a close, low-scoring game. In Bo Nix’s first game on the road last year, they scored 20 so maybe a touchdown spread could work out.

I’ll probably just wait until Week 1 is just around the corner to see where things stand then though, but if you twisted my arm I’d probably take the under this far out.